Cancer scientists have long debated whether all cells within a tumour are equal or whether some cancer cells are more potent – a question that has been highly investigated in experimental models in the last decade. Research published in Nature Medicine (10.1038/nm.2415) focuses on patients and shows that acute myeloid leukemia (AML) contains rare cells ...
Bristol-Myers Squibb today announced that SPRYCEL (dasatinib) received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) for the treatment of adult patients with newly diagnosed Philadelphia chromosome positive Chronic Myelogenous Leukaemia in Chronic Phase (CML-CP). This decision follows the presentation of results from the pivotal DASISION study in which dasatinib ...
In the quest to arrest the growth and spread of tumors, there have been many attempts to get cancer genes to ignore their internal instruction manual. In a new study, a team led by Dana-Farber Cancer Institute scientists has created the first molecule able to prevent cancer genes from “hearing” those instructions, stifling the cancer ...
Virginia Commonwealth University Massey Cancer Center researcher Steven Grant, M.D., and a team of VCU Massey researchers have uncovered the mechanism by which leukemia cells trigger a protective response when exposed to a class of cancer-killing agents known as histone deacetylase inhibitors (HDACIs). The findings, published in the Journal of Biological Chemistry, could lead to ...
A team of researchers lead by Fatih M. Uckun, MD, PhD, of The Saban Research Institute of Childrens Hospital Los Angeles has determined that radiation resistance in leukemia can be overcome by selectively attacking a molecular target known as SYK tyrosine kinase. B-lineage acute lymphoblastic leukemia (ALL) is the most common cancer occurring in children ...
