Advertiment
Predicting Non-Sentinel Lymph Node Status in Breast Cancer Patients with Sentinel Lymph Node Involvement: Evaluation of Two Scoring Systems.
Sanjuán A, Escaramís G, Vidal-Sicart S, Illa M, Zanón G, Pahisa J, Rubí S, Velasco M, Santamaría G, Farrús B, Muñoz M, García Y, Fernández PL, Pons F.
Department of Gynecology & Obstetrics, Hospital Clínic, University of Barcelona, Spain.
The aim of this study was to validate a nomogram and a scoring system to predict non-sentinel lymph node status in breast cancer patients with sentinel lymph node (SLN) involvement. A total of 516 breast cancer patients underwent sentinel lymph node biopsy at our institution from January 2001 to August 2006. A prospective database was used to identify breast cancer patients with a positive SLN biopsy examination who underwent a completion axillary lymph node dissection. A total of 114 patients were identified. The Memorial Sloan-Kettering Cancer Center (MSKCC) nomogram and an axilla scoring system from Paris (Hôpital Tenon) were used to predict the probability of having non-SLN involvement. One hundred fourteen patients were included in the study. The areas under the receiver operating characteristics (ROC) curves were 0.671 (95% CI: 0.552-0.790) for the MSKCC nomogram and 0.703 (95% CI: 0.596-0.811) for the Tenon score. The univariate analysis shows that size of SLN metastases, the number of positive and negative SLN and the proportion of positive SLN were statistically significant. On multivariate logistic regression analysis, the size of SLN metastases and the proportion of positive SLN were statistically significant. The two scoring systems are similar according to their area under ROC curves, but should be improved to be valid and determinant to the general population. Meanwhile, the use of scoring systems could be applied in an individual manner in some patients.
Breast J. 2010 Jan 29.
Leave a Reply
Suggested Posts
Vaccine for metastatic breast, ovarian cancer shows promise Predicti g No -Se ti el Lymph Node Status i Breast Ca cer Patie ts with Se ti el Lymph Node I volveme t: Evaluatio of Two Scori g Systems. Sa juá A, Escaramís G, Vidal-Sicart S, Illa M, Za ó G, Pahisa J, Rubí S, Velasco M, Sa tamaría G, Farrús B, Muñoz M, García Y, Fer á dez PL, Po s F. Departme t of Gy ecology & Obstetrics, Hospital Clí ic, U iversity [...]. Posted February 4th, 2010 | 9:11 am
Fungal Toxins Found in Urine of Young Girls Could Impact Future Risk of Breast Cancer Predicti g No -Se ti el Lymph Node Status i Breast Ca cer Patie ts with Se ti el Lymph Node I volveme t: Evaluatio of Two Scori g Systems. Sa juá A, Escaramís G, Vidal-Sicart S, Illa M, Za ó G, Pahisa J, Rubí S, Velasco M, Sa tamaría G, Farrús B, Muñoz M, García Y, Fer á dez PL, Po s F. Departme t of Gy ecology & Obstetrics, Hospital Clí ic, U iversity [...]. Posted February 4th, 2010 | 9:11 am
Blue Shield of California won’t cover the breast cancer drug Avastin Predicti g No -Se ti el Lymph Node Status i Breast Ca cer Patie ts with Se ti el Lymph Node I volveme t: Evaluatio of Two Scori g Systems. Sa juá A, Escaramís G, Vidal-Sicart S, Illa M, Za ó G, Pahisa J, Rubí S, Velasco M, Sa tamaría G, Farrús B, Muñoz M, García Y, Fer á dez PL, Po s F. Departme t of Gy ecology & Obstetrics, Hospital Clí ic, U iversity [...]. Posted February 4th, 2010 | 9:11 am
Boehringer Ingelheim Broadens its Breast Cancer Trial Programme for Afatinib Predicti g No -Se ti el Lymph Node Status i Breast Ca cer Patie ts with Se ti el Lymph Node I volveme t: Evaluatio of Two Scori g Systems. Sa juá A, Escaramís G, Vidal-Sicart S, Illa M, Za ó G, Pahisa J, Rubí S, Velasco M, Sa tamaría G, Farrús B, Muñoz M, García Y, Fer á dez PL, Po s F. Departme t of Gy ecology & Obstetrics, Hospital Clí ic, U iversity [...]. Posted February 4th, 2010 | 9:11 am
Targeted Therapies in Breast Cancer – Oxford American Pocket Notes Predicti g No -Se ti el Lymph Node Status i Breast Ca cer Patie ts with Se ti el Lymph Node I volveme t: Evaluatio of Two Scori g Systems. Sa juá A, Escaramís G, Vidal-Sicart S, Illa M, Za ó G, Pahisa J, Rubí S, Velasco M, Sa tamaría G, Farrús B, Muñoz M, García Y, Fer á dez PL, Po s F. Departme t of Gy ecology & Obstetrics, Hospital Clí ic, U iversity [...]. Posted February 4th, 2010 | 9:11 am